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KMID : 0613820130230020319
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Journal of Life Science
2013 Volume.23 No. 2 p.319 ~ p.323
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Various Aggregate Forms of Tryptophan Synthase α-Subunit
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Park Myung-Won
Lim Woon-Ki
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Abstract
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Protein aggregation can cause diseases and hinder the production of useful recombinant proteins. The present study showed that at least three types of aggregates can be formed from tryptophan synthase α-subunit (αTS) by varying conditions: (1) an opaque white precipitous aggregate, (2) a transparent gel-like precipitous aggregate, and (3) an unprecipitous aggregate. Macroscopically different aggregate types might suggest different mechanisms underlying aggregation processes.
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KEYWORD
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Opaque white aggregate, protein aggregate, transparent gel-like aggregate, tryptophan synthase α-subunit, unprecipitous aggregate
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